Gene Mutation: The Hair loss

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Researchers have identified a new gene which is involved in hair growth and also found the gene mutation which is responsible for hypotrichosis simplex, a hereditary hair loss disorder which is affecting people nowadays. The disorder causes hair follicle miniaturization, a process in which hair follicles shrink and narrow, and thick hair is supplanted by fine, downy "peach fuzz" hair. This discovery may affect the future researches and treatments for the male pattern baldness and other forms of hair loss.

The identification of this gene basic hereditary hypotrichosis simplex has managed us an opportunity to gain understanding into the method of hair follicle miniaturization, which is most commonly watched in male pattern hair loss or androgenetic alopecia. It is important to note that whereas these two conditions share the same physiologic process, the gene researchers found for genetic hypotrichosis does not clarify the complex process of male pattern hair loss.

The team researchers made their data by analyzing genetic data from few families and from countries like Pakistan and Italy who have hereditary hypotrichosis simplex. After analysis they found a common mutation in the APCDD1 gene, which is found in a particular region on chromosome 18 that has been appeared in past studies to be involved in other shapes of hair loss, counting androgenetic alopecia and alopecia areata, implying at a broader part in hair follicle biology.

Importantly, the analysts found that APCDD1 inhibits a signaling pathway that has long been appeared to control hair development in mouse models but has not been broadly connected to human hair development. Laboratory researchers have focused on this pathway, known as the Wnt signaling pathway, to turn on or off hair development in mice, but, until presently, the pathway did not show up to be included in human hair loss. This finding is significant since it gives evidence that hair growth patterns in people and in mice are more similar than already accepted.

These findings suggest that manipulating the Wnt pathway may have an effect on hair follicle growth for the first time, in humans And unlike commonly available treatments for hair loss that involve blocking hormonal pathways. They are now working to understand the complex genetic causes of other forms of hair loss including alopecia areata, with the hope of eventually developing new, effective treatments for these conditions.